Dr. Fei Chen is currently a Fellow at the Broad Institute. He obtained his Ph.D. in biological engineering from the Massachusetts Institute of Technology in 2016.


Fei Chen, Principal Investigator

Dr. Fei Chen is currently a Fellow at the Broad Institute. He obtained his Ph.D. in biological engineering from the Massachusetts Institute of Technology in 2016. During the course of his doctoral research, Fei co-invented expansion microscopy, a breakthrough technique that allows for super-resolution imaging of biological samples with conventional light microscopes. He continues to pioneer novel molecular and microscopy tools to uniquely illuminate biological pathways and function.

Fei was an Axline scholar at the California Institute of Technology and graduated with a Bachelor's degree in Electrical Engineering in 2011. His awards and funding include the National Science Foundation Graduate Research Fellowship, the MIT Viterbi and Poitras Fellowships, and the Forbes 30 under 30: Class of 2019.


Tongtong Zhao, Postdoc

Tongtong is a joint postdoc with the Buenrostro lab and interested in developing in situ techniques to characterize epigenomic heterogeneity and trace lineages in tumors. She received her Ph.D. in genetics from the University of Cambridge, where she used in vivo time-lapse microscopy to uncover a novel mechanism for nuclear positioning. She did her undergraduate studies at the University of Heidelberg, Germany, and Imperial College London. Her awards include the Human Frontier Science Program Long-term fellowship, Jane Coffin Childs postdoctoral fellowship, Boehringer Ingelheim Fonds Ph.D. scholarship, and undergraduate fellowship of the German Academic Scholarship Foundation (“Studienstiftung”).


Haiqi Chen, Postdoc

Haiqi Chen is a postdoctoral associate at the Broad Institute. Prior to joining the Chen Lab, Haiqi was a predoctoral research fellow in the Population Council at Rockefeller University, studying reproductive biology and infertility. He has produced over 20 publications, including original research articles, reviews and book chapters on topics ranging from spermatogenesis to Zika virus. Haiqi received his Ph.D. in molecular and cell biology from the University of Hong Kong and his Bachelor’s degree in pharmaceutical sciences from China Medical University. He is currently developing novel tools for cellular recording and for studying dynamic interactions between cells in vivo.

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Sophia Liu, Graduate Student

Sophia Liu is a graduate student in the Harvard Biophysics program and affiliated with the Harvard-MIT Health Sciences and Technology (HST) Medical Engineering and Medical Physics (MEMP) program. She is jointly a member of the the Chen Lab and Eric Lander's Lab. Sophia graduated with a Bachelor’s degree in chemical-biological engineering from MIT, and worked as an undergraduate in Robert Langer's Lab and Alex Shalek's Lab. She is interested in applying molecular biology to create tools to understand cellular dynamics.

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Andrew Payne, Graduate Student

Andrew is a joint graduate student with the Boyden lab. He graduated in Engineering Science at the University of Toronto, and was a former visiting student at the MIT Media Lab and at the Harvard Wyss Institute. Andrew is currently interested in developing new strategies for high resolution light microscopy.


Linlin Chen, Research Associate

Linlin is a Research Associate in the Chen lab. She graduated from Wellesley College in 2017 with a B.A. in Neuroscience, and worked as an undergraduate in the Synthetic Neurobiology Group at MIT. She is interested in developing molecular tools to further our understanding of the brain.

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Sam Sturner, Research Associate

Sam is a Research Associate and jointly a member of the Macosko Lab in the Stanley Center for Psychiatric Research at the Broad Institute. He graduated with a B.S. in Physiology and Neurobiology from the University of Maryland. Previously, he has worked on leveraging micro- and nanoengineering approaches to elucidate how single cells interact with the diverse physical and mechanical cues of the extracellular microenvironment. Sam continues to be interested in developing and applying single cell analysis strategies to study developmental and pathological trajectories in the central nervous system. To this end, he is currently interested in building new molecular technologies for expanding the functional classes of data that can be obtained from single cell sequencing workflows.


Jaime Marshall, Affiliate

Jamie Marshall is the Associate Director of the Kidney Disease Initiative and jointly a member of the Chen lab. Jamie obtained her PhD from Rachelle Crosbie-Watson’s lab at UCLA, where she studied the role of sarcospan in the pathogenesis of muscular dystrophy and the mechanism of sarcospan-mediated amelioration of disease. In her postdoc with Louis Kunkel at Boston Children’s Hospital, she studied therapeutic approaches with heme oxygenase and a novel PDE inhibitor in collaboration with Pfizer. As a research scientist in Daniel MacArthur’s lab at the Broad Institute, Jamie performed functional validation of potential disease causing variants from Rare Disease patients and studied the therapeutic and disease potential of rare loss-of-function variants observed in healthy controls from gnomAD. In the Chen/Greka labs, Jamie is interested in applying technologies to develop a detailed spatial transcriptome map of healthy and diseased kidneys and in developing technologies to explain the functional significance of all genetic variants.

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Sam Rodriques, Affiliate

Sam is a graduate student in the physics department at MIT. Previously, he graduated from Haverford College with a degree in physics and spent two years at the University of Cambridge studying applied mathematics and computational neuroscience. In the Boyden lab, he is developing tools to help further understand the development and functions of the brain.

Lab Alumni

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Evan Murray, Research Associate

Evan is a Research Associate at the Broad Institute, having graduated with a B.S. in biology and an M.S. in neuroscience from the Massachusetts Institute of Technology. Evan previously worked on optimizing the CLARITY pipeline, and also co-invented the Stochastic Electrotransport and SWITCH technologies to enable scalable, uniform labeling and subsequent 3D imaging of large tissue samples with conventional molecular probes and light microscopes. Evan continues to be interested in developing technologies for creating high-dimensional “omics” datasets to enable further understanding of the brain.


Shirin Shivaei, MS

Shirin is an M.Eng student in the EECS department at MIT. She graduated with a B.S. in Electrical Engineering from MIT and previously worked on developing inexpensive, fast imaging microscopy methods for histopathology of breast tissue. She is currently interested in developing tools for high resolution single-cell sequencing and protein characterization.


Sam Padula, Undergraduate

Sam Padula came to the Chen Lab for the Summer of 2018 and liked it so much that he decided not to leave. He spent his first two years of undergrad at Wofford College and plans to continue his formal education after gaining some more research experience. He is interested in directed evolution and recording cellular activity.