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Publications

Updated publications from the Chen Lab at the Broad Institute.

Publications

Rodriques S.G., Stickels R.R., Goeva A., Martin C.A., Murray E., Vanderburg C.R., Welch J., Chen L.M., Chen F.*, Macosko E.* Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution. Science. (*Corresponding author) [Publisher link]

2019


Asano S.M., Gao. R., Wassie. A.T., Tillberg P.W., Chen F., Boyden E.S. Expansion Microscopy: Protocols for Imaging Proteins and RNA in Cells and Tissues. Current Protocols in Cell Biology. [Publisher link]

2018


2017

Zhao Y., Bucur O., Irshad H., Chen F., Weins A., Stancu A.L., Oh E-Y., DiStasio M., Torous V., Glass B., Stillman I.E., Schnitt S.J., Beck A.H., Boyden E.S. Nanoscale Imaging of Clinical Specimens Using Pathology-Optimized Expansion Microscopy. Nature Biotechnology. [Publisher link] [PDF]

Chang J.B., Chen F., Yoon Y.G., Jung E. E., Babcock H., Kang J.S., Asano S., Suk H.J., Pak N., Tillberg P.W., Wassie A., Cai D., Boyden E.S. Iterative expansion microscopy. Nature Methods. [Publisher link] [PDF]


2016

Chen F.*, Wassie A.T.*, Cote A.J., Sinha A., Alon S., Asano S., Daugharthy E.R., Chang J.-B., Marblestone A., Church G.M., Raj A., Boyden E.S. Nanoscale Imaging of RNA with Expansion Microscopy. Nature Methods. (*equal contribution) [Publisher link] [PDF]

Tillberg P.W.*, Chen F.*, Piatkevich K.D., Zhao Y., Yu C.-C., English B.P., Gao L., Martorell A., Suk H.-J., Yoshida F., DeGennaro E.M., Roossien D.H., Gong G., Seneviratne U., Tannenbaum S.R., Desimone R., Cai D., Boyden E.S. (2016) Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies. Nature Biotechnology. (*equal contribution) [Publisher link] [PDF]

Zhang Y.S., Chang J.B., Alvarez M.M., Trujillo-de Santiago G., Aleman J., Batzaya B., Kirshnadoss V., Ramanujam A.A., Kazemzadeh-Narbat M., Chen F., Tillberg P.W., Dokmeci M.R., Boyden E.S., Khademhosseini A. Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications. Scientific Reports. [Publisher link] [PDF]


2015

Chen F.*, Tillberg P.W.*, Boyden E.S. Expansion Microscopy. Science. 347(6221):543-548. (*equal contribution) [Publisher link] [PDF]


2014

Schmidt D., Tillberg P.W.*, Chen F.*, Boyden E.S. A fully genetically encoded protein architecture for optical control of peptide ligand concentration. Nature Communications. (*equal contribution)  [Publisher link] [PDF]