Updated publications from the Chen Lab at the Broad Institute.


Rodriques S.G., Stickels R.R., Goeva A., Martin C.A., Murray E., Vanderburg C.R., Welch J., Chen L.M., Chen F.*, Macosko E.* Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution. Science. (*Corresponding author) [Publisher link]


Asano S.M., Gao. R., Wassie. A.T., Tillberg P.W., Chen F., Boyden E.S. Expansion Microscopy: Protocols for Imaging Proteins and RNA in Cells and Tissues. Current Protocols in Cell Biology. [Publisher link]



Zhao Y., Bucur O., Irshad H., Chen F., Weins A., Stancu A.L., Oh E-Y., DiStasio M., Torous V., Glass B., Stillman I.E., Schnitt S.J., Beck A.H., Boyden E.S. Nanoscale Imaging of Clinical Specimens Using Pathology-Optimized Expansion Microscopy. Nature Biotechnology. [Publisher link] [PDF]

Chang J.B., Chen F., Yoon Y.G., Jung E. E., Babcock H., Kang J.S., Asano S., Suk H.J., Pak N., Tillberg P.W., Wassie A., Cai D., Boyden E.S. Iterative expansion microscopy. Nature Methods. [Publisher link] [PDF]


Chen F.*, Wassie A.T.*, Cote A.J., Sinha A., Alon S., Asano S., Daugharthy E.R., Chang J.-B., Marblestone A., Church G.M., Raj A., Boyden E.S. Nanoscale Imaging of RNA with Expansion Microscopy. Nature Methods. (*equal contribution) [Publisher link] [PDF]

Tillberg P.W.*, Chen F.*, Piatkevich K.D., Zhao Y., Yu C.-C., English B.P., Gao L., Martorell A., Suk H.-J., Yoshida F., DeGennaro E.M., Roossien D.H., Gong G., Seneviratne U., Tannenbaum S.R., Desimone R., Cai D., Boyden E.S. (2016) Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies. Nature Biotechnology. (*equal contribution) [Publisher link] [PDF]

Zhang Y.S., Chang J.B., Alvarez M.M., Trujillo-de Santiago G., Aleman J., Batzaya B., Kirshnadoss V., Ramanujam A.A., Kazemzadeh-Narbat M., Chen F., Tillberg P.W., Dokmeci M.R., Boyden E.S., Khademhosseini A. Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications. Scientific Reports. [Publisher link] [PDF]


Chen F.*, Tillberg P.W.*, Boyden E.S. Expansion Microscopy. Science. 347(6221):543-548. (*equal contribution) [Publisher link] [PDF]


Schmidt D., Tillberg P.W.*, Chen F.*, Boyden E.S. A fully genetically encoded protein architecture for optical control of peptide ligand concentration. Nature Communications. (*equal contribution)  [Publisher link] [PDF]