Principal Investigator

Dr. Fei Chen is currently a Core Faculty member at the Broad Institute and assistant professor at Harvard Stem Cell and Regenerative Biology. He obtained his Ph.D. in biological engineering from the Massachusetts Institute of Technology in 2016. Fei was a Schmidt Fellow at the Broad Institute from 2017-2020.

Postdoctoral Associate

Dawei Sun is a Postdoctoral Associate at the Broad Institute. He graduated from the Gurdon Institute, University of Cambridge, under the supervision of Dr. Emma Rawlins, where he used single cell sequencing, CRISPRi screen and organoid approaches to study human lung development. In the Chen Lab, he is currently seeking to combine functional genomics and spatial techniques to investigate tissue development and regeneration.

Postdoctoral Associate

Dongshunyi (Dora) Li is a EWSC Postdoctoral Fellow at the Broad Institute, jointly advised by Caroline Uhler. She obtained her Ph.D. in computational biology from Carnegie Mellon University under the supervision of Ziv Bar-Joseph, where she developed machine learning (ML) methods to study cell-cell interactions and their impact on dynamic biological processes using spatio-temporal single cell data. Dora is currently interested in building ML methods to learn multi-scale spatial interactions and organizations from spatial transcriptomics data.

Postdoctoral Associate

Yunhao Bai is a postdoc associate at the Broad Institute. He obtained his Ph.D. in Chemistry from Stanford University under the supervision of Prof. Garry Nolan, where he mainly focused on combining Expansion Microscopy with Mass Spectrometry Imaging for proteomics and glycomics. Before that, Yunhao graduated with a B.S. in Chemistry from Tsinghua University. His current interests lie in highly-multiplexed spatial techniques with super-resolution or in living systems.

Postdoctoral Associate

Hung-Che (Jami) Kuo is a postdoctoral associate at the Broad Institute. He’s a joint member of the Chen Lab and Jason Buenrostro Lab. He earned his Ph.D. in Cell and Molecular Biology from the University of Texas at Austin under the guidance of Dr. Ilya Finkelstein, where he developed high-throughput RNA-protein interaction profiling methods to explore the specificity of CRISPR-Cas13 and its applications in CRISPR diagnostics. Currently, Jami is focused on developing methods for high-throughput profiling of protein-nucleic acid and protein-protein interactions.

Postdoctoral Associate

Postdoctoral Associate

Graduate Student

Chenlei Hu graduated from Peking University with a B.S. in Biological Science and Physics. Before going to graduate school, she explored research in Drosophila development, cell biology of nuclear protein, as well as biophysics of cytoplasm and cytoskeleton. Now Chenlei is a graduate student in the Harvard MCO program. In the Chen lab, she wants to know more about how cells are organized subcellularly and use the knowledge to engineer the cellular machine.

Graduate Student

Jackson Weir is a Harvard graduate student in the Biological and Biomedical Sciences program. He previously graduated from the University of New Brunswick with a B.Sc. in Cellular and Molecular Biology. During undergrad, he researched blood cancer biology and studied new ways to activate the anti-cancer immune response. In the Chen Lab, Jackson is interested in developing spatial omics technology to answer key questions in cancer evolution and tumor microenvironment dynamics.

Graduate Student

Sandeep Kambhampati is a graduate student in the Harvard Bioinformatics and Integrative Genomics (BIG) PhD program. He graduated in 2021 with a B.S. in Biomedical Engineering from Johns Hopkins, where he worked in the labs of Chulan Kwon and Andrew Feinberg. He joined the Chen lab with an interest in using machine learning approaches to draw biological insights from new types of genomics data. He is excited about using spatial genomics to build ML models of tissue organization in order to study how this organization arises during development and is disrupted during disease.

Graduate Student

Benno Orr is a graduate student in the Harvard Biological and Biomedical Sciences program. He completed a B.Sc. in Molecular Genetics and Microbiology at the University of Toronto and worked in Dr. Ronald Cohn’s lab at SickKids. Benno is interested in spatial perturbation screens.

Graduate Student

Kevin is pursuing his graduate studies in the Chemical Physics program at Harvard University. He holds a Master of Science in Chemistry from National Chiao Tung University. Prior to enrolling in the Harvard CCB program, his research focused on exploring the connection between cardiovascular disease and gut microbiota and investigating the biophysical characteristics of cardiomyocytes using multiphoton microscopy. Kevin is developing genomics tools to gain insights into tissue dynamics.

Graduate Student

Maile is a graduate student in the Harvard Systems, Synthetic and Quantitative Biology program. She graduated from MIT with a B.S. in Biological Engineering. During undergrad, she worked in Dave Bartel’s lab researching the systematic requirements of how microRNAs are selectively degraded by mRNAs and lncRNAs. In the Chen Lab, Maile is interested in building molecular tools for cell-type specificity and temporal recording.

Graduate Student

Jake is a graduate student in the Biophysics Program at Harvard. Previously, he studied computer science and molecular biology at MIT. There, he worked in the Langer Lab to develop a therapy for cardiovascular disease-related diabetes, with forays into computational protein design and LNP drug delivery. In the Chen Lab, Jake is interested in developing technologies that enable measurements in tissue that we can’t yet make. He then hopes to apply these methods to develop therapies for cancer. Outside of the lab, Jake likes to hike, blow glass, and play basketball with his labmates.

Graduate student

Claudia is a Harvard graduate student in the Bioinformatics and Integrative Genomics Program PhD program. She graduated from Georgia Tech with a B.S. in computer science and minor in biology. Prior to starting graduate school, she worked in Dr. Gad Getz's lab in cancer genomics data analysis and method development. In the Chen lab, she is interested in using new single cell and spatial genomics tools to understand the development, maintenance, and deterioration of multicellular systems.

Graduate Student

Dana is a graduate student in the Harvard Biophysics program. She graduated from the University of Chicago with a B.S. in Molecular Engineering and B.A. in Physics. During undergrad, she studied the dispersal of biomolecular condensates with single-molecule fluorescence microscopy in Dr. Allison Squires’ lab, and developed analysis methods for genome-scale language models in Dr. Arvind Ramanathan’s lab. In the Chen Lab, Dana is interested in developing technologies to understand and engineer multicellular signaling spatially and temporally.

Graduate Student

Dan Lesman is an MD-PhD student in the Harvard Biophysics program. He completed his B.S. in Biomedical Science at The Ohio State University. Dan is interested in building tools to better understand the role of circulating proteins in physiology.

Graduate Student

Yonit is a graduate student in the Molecules, Cells, and Organisms program at Harvard. As an undergraduate at Princeton, she studied mammalian early embryonic development and cell fate decisions using gene editing and live imaging techniques. Yonit is currently interested in characterizing how complex multicellular organisms communicate and coordinate physiology across diverse tissues and throughout their lifespan.

Undergraduate Student

Julianne is an undergraduate at Harvard College, concentrating in Chemical & Physical Biology and Economics. She’s previously researched sex-specific signaling pathways associated with cardiovascular disease under Dr. Jennifer DuPont at Tufts Medical Center. In the Chen Lab, she’s excited to rationally engineer diverse immune structures. She can often be found perusing art galleries, running along the Charles, or sampling new pastries.

Manager, Laboratory Operations

Giovanni graduated from Syracuse University in 2019 with a B.S. in Biotechnology. Previously, he studied regulatory T cells in adipose tissue in Louise D’Cruz’s lab at the University of Pittsburgh. Giovanni will be developing Slide-Seq & genomic technologies in the Chen Lab.

Executive Assistant

Jared Spencer is the Executive Assistant to Fei Chen and his lab. Born and raised in Cambridge, Jared ventured off to Purdue University and earned a B.S. in Hospitality and Tourism Management. In the last several years, Jared worked in the luxury hotel industry.

Lab AI assistant

Everyone has a lobster in Boston

We are looking for you!

Email chenf@broadinstitute.org if you want to join the Chen lab family!